Tacrolimus EP Impurity E

Chemical Name: (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-[(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-propyl-3,4,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-octadecahydro-7H-15,19-epoxypyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone (as per EP); (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)- 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-{(E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylvinyl}-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-8-propyl-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone (as per USP)

Synonym: NULL

Smile: O[C@H]1[C@H](OC)C[C@H](/C=C(C)/[C@@H](OC([C@@H]2N(C(C([C@@]3(O)[C@H](C)C[C@H](OC)[C@]4([H])O3)=O)=O)CCCC2)=O)[C@H](C)[C@@H](O)CC([C@H](CCC)/C=C(C[C@H](C)C[C@@H]4OC)\C)=O)CC1