Tacrolimus open ring Impurity

Chemical Name: (3S,4R,5S,8R,12S,14S,15R,16S,18R,26aS,E)-8-Allyl-5,6,11,12,13,14,15,16,17,18,24,25,26,26a-tetradecahydro-5,15,20,20-tetrahydroxy-3-{(E)-2-[1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]- 1-methylvinyl}-14,16-dimethoxy-4,10,12,18-tetramethyl-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,19,21(4H,8H,20H,23H)-tetrone (as per USP)

Smile: O=C([C@@](CCCC1)([H])N1C(C(O)(O)C([C@H](C)C[C@H](OC)[C@H](O)[C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H]2CC=C)=O)=O)O[C@H](/C(C)=C/[C@H]3C[C@@H](OC)[C@H](O)CC3)[C@H](C)[C@@H](O)CC2=O