Afatinib

Afatinib Related Products

Venkatasai is a leading innovator in the field of pharmaceutical reference standards, offering high-quality Reference Standards of Afatinib, including both pharmacopeial and non-pharmacopeial impurities, metabolites, stable isotope-labeled compounds, and nitrosamines (N-NO products). Our Afatinib impurity reference standards play a vital role in pharmaceutical research, supporting product development, ANDA and DMF filings, quality control (QC), method validation, and stability studies. They are also instrumental in identifying unknown impurities and evaluating genotoxic potential. All Afatinib-related products are thoroughly characterized and supplied with comprehensive Certificates of Analysis (COA) and analytical data that comply with regulatory standards. EP/USP traceable standards can also be provided upon request. Furthermore, all supplied products undergo periodic re-testing to ensure continued quality and reliability.

Afatinib

(S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
CAT No: VS-A026000
CAS No: 850140-72-6
Mol.F.: C24H25ClFN5O3
Mol.Wt.: 486
Status: Custom Synthesis

Afatinib Butoxy Analog

(E)-N-(7-Butoxy-4- ((3-chloro-4fluoroophenyl)amino)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
CAT No: VS-A026016
CAS No: N/A
Mol.F.: C24H27ClFN5O2
Mol.Wt.: 472
Status: Custom Synthesis

Afatinib D6

(S,E)-4-(Bis(methyl-d3)amino)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide
CAT No: VS-A026058
CAS No: NA
Mol.F.: C24H19D6ClFN5O3
Mol.Wt.: 492.0
Status: Custom Synthesis

Afatinib Dimaleate

(S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide dimaleate
CAT No: VS-A026013
CAS No: 850140-73-7
Mol.F.: C24H25ClFN5O3 . C8H8O8
Mol.Wt.: 485.9 :?232.1
Status: Custom Synthesis

Afatinib Impurity 10

(E)-N-(4-((3-Chloro-4-fluorophenyl)(4-((4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)-1-(dimethylamino)-4-oxobutan-2-yl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
CAT No: VS-A026025
CAS No: N/A
Mol.F.: C48H50Cl2F2N10O6?
Mol.Wt.: 971.9
Status: Custom Synthesis

Afatinib Impurity 11

(S)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-3-enamide
CAT No: VS-A026026
CAS No: 2413212-17-4
Mol.F.: C22H20ClFN4O3?
Mol.Wt.: 442.9
Status: Custom Synthesis

Afatinib Impurity 12

(S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-hydroxybut-2-enamide ; 4-Hydroxy 4-Dedimethylamino Afatinib
CAT No: VS-A026027
CAS No: 2121530-37-6
Mol.F.: C22H20ClFN4O4?
Mol.Wt.: 458.9
Status: Custom Synthesis

Afatinib Impurity 13

1-(4-((3-chloro-4-fluorophenyl)amino)-7-(((R)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one ; Des-(4-dimethylamino-2-en-1-oxo)butylamino 6-(5-Hydroxy-pyrrolidin-2-on-1-yl) Afatinib
CAT No: VS-A026028
CAS No: 2413212-19-6
Mol.F.: C22H20ClFN4O4?
Mol.Wt.: 458.9
Status: Custom Synthesis

Afatinib Impurity 14

(S)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((R)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)-3-hydroxybutanamide
CAT No: VS-A026029
CAS No: 2413212-21-0
Mol.F.: C24H27ClFN5O4?
Mol.Wt.: 504
Status: Custom Synthesis

Afatinib Impurity 15

(R)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-(((R)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)-3-hydroxybutanamide
CAT No: VS-A026030
CAS No: 2413212-23-2
Mol.F.: C24H27ClFN5O4?
Mol.Wt.: 504
Status: Custom Synthesis

Afatinib Impurity 16

(S)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)acetamide ; Des(4-dimethylamino-2-en-1-oxo)butyl Afatinib N6 Formyl
CAT No: VS-A026031
CAS No: N/A
Mol.F.: C19H16ClFN4O3?
Mol.Wt.: 402.8
Status: Custom Synthesis

Afatinib Impurity 17

(S)-N-(1-((4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)ethylidene)-N-methylmethanaminium
CAT No: VS-A026032
CAS No: N/A
Mol.F.: C21H22ClFN5O2?
Mol.Wt.: 430.9
Status: Custom Synthesis

Afatinib Impurity 18

(S,E)-4-(dimethylamino)-N-(4-((4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide
CAT No: VS-A026033
CAS No: 2413212-25-4
Mol.F.: C24H26FN5O3?
Mol.Wt.: 451.5
Status: Custom Synthesis

Afatinib Impurity 19

(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)-4-(dimethylamino)but-2-enamide
CAT No: VS-A026034
CAS No: 1245555-42-3
Mol.F.: C21H21ClFN5O2?
Mol.Wt.: 429.9
Status: Custom Synthesis

Afatinib Impurity 2

4-((4-chloro-3-fluorophenyl)amino)-6-nitroquinazolin-7-ol
CAT No: VS-A026017
CAS No: 2475094-95-0
Mol.F.: C14H8ClFN4O3?
Mol.Wt.: 334.7
Status: Custom Synthesis

Afatinib Impurity 20

(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-4-(dimethylamino)but-2-enamide
CAT No: VS-A026035
CAS No: 1957132-02-3
Mol.F.: C22H23ClFN5O2?
Mol.Wt.: 443.9
Status: Custom Synthesis

Afatinib Impurity 21

(S)-N4-(3,4-difluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
CAT No: VS-A026036
CAS No: 2044709-72-8
Mol.F.: C18H16F2N4O2?
Mol.Wt.: 358.4
Status: Custom Synthesis

Afatinib Impurity 22

(S)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)acetamide
CAT No: VS-A026037
CAS No: N/A
Mol.F.: C20H18ClFN4O3
Mol.Wt.: 416.8
Status: Custom Synthesis

Afatinib Impurity 23

N-(4-Chloro-3-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine
CAT No: VS-A026038
CAS No: 2475095-50-0
Mol.F.: C14H7ClF2N4O2
Mol.Wt.: 336.7
Status: Custom Synthesis

Afatinib Impurity 24

Ethyl (E)-4-(dimethylamino)but-2-enoate hydrochloride
CAT No: VS-A026039
CAS No: 1255078-56-8
Mol.F.: C8H15NO2 : HCl
Mol.Wt.: 157.2 : 36.5
Status: Custom Synthesis

Afatinib Impurity 25

Methyl (E)-4-(dimethylamino)but-2-enoate
CAT No: VS-A026040
CAS No: 212776-19-7
Mol.F.: C7H13NO2
Mol.Wt.: 143.2
Status: Custom Synthesis

Afatinib Impurity 26

(S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine
CAT No: VS-A026041
CAS No: 314771-88-5
Mol.F.: C18H14ClFN4O4
Mol.Wt.: 404.8
Status: Custom Synthesis

Afatinib Impurity 27

Diethyl (S)-(2-((4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)-2-oxoethyl)phosphonate
CAT No: VS-A026042
CAS No: 618061-76-0
Mol.F.: C24H27ClFN4O6P
Mol.Wt.: 552.9
Status: Custom Synthesis

Afatinib Impurity 28

1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-2-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one
CAT No: VS-A026043
CAS No: N/A
Mol.F.: C22H20ClFN4O4
Mol.Wt.: 458.9
Status: Custom Synthesis

Afatinib Impurity 29

Ethyl hydrogen (2-((4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)-2-oxoethyl)phosphonate
CAT No: VS-A026044
CAS No: N/A
Mol.F.: C22H23ClFN4O6P
Mol.Wt.: 524.9
Status: Custom Synthesis

Afatinib Impurity 3

N-(4-chloro-3-fluorophenyl)-7-fluoro-8-nitroquinazolin-4-amine ; (3-Chloro-4-fluorophenyl)(7-fluoro-6-nitroquinazolin-4-yl)amine
CAT No: VS-A026018
CAS No: 2475094-96-1
Mol.F.: C14H7ClF2N4O2?
Mol.Wt.: 336.7
Status: Custom Synthesis

Afatinib Impurity 30

Methyl (E)-4-(Dimethylamino)but-2-enoate
CAT No: VS-A026045
CAS No: 501332-25-8
Mol.F.: C7H13NO2
Mol.Wt.: 143.2
Status: Custom Synthesis

Afatinib Impurity 31

1-(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one
CAT No: VS-A026046
CAS No: 2223677-58-3
Mol.F.: C22H20ClFN4O4
Mol.Wt.: 458.9
Status: Custom Synthesis

Afatinib Impurity 33

(E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-hydroxyquinazolin-6-yl)-4-(dimethylamino)but-2-enamide
CAT No: VS-A026060
CAS No: 2223677-61-8
Mol.F.: C20H19ClFN5O2
Mol.Wt.: 415.9
Status: Custom Synthesis

Afatinib Impurity 4

N-(3,4-dichlorophenyl)-7-fluoro-6-nitroquinazolin-4-amine
CAT No: VS-A026019
CAS No: 2512206-82-3
Mol.F.: C14H7Cl2FN4O2?
Mol.Wt.: 353.1
Status: Custom Synthesis

Afatinib Impurity 5

N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitro-4-quinazolinamine
CAT No: VS-A026020
CAS No: 179552-74-0
Mol.F.: C15H10ClFN4O3?
Mol.Wt.: 348.7
Status: Custom Synthesis

Afatinib Impurity 6

N-(4-chloro-3-fluorophenyl)-7-fluoro-8-nitroquinazolin-4-amine ; (S)-N4-(4-Fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
CAT No: VS-A026021
CAS No: N/A
Mol.F.: C18H17FN4O2?
Mol.Wt.: 340.4
Status: Custom Synthesis

Afatinib Impurity 7

(S)-N4-phenyl-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
CAT No: VS-A026022
CAS No: N/A
Mol.F.: C18H18N4O2?
Mol.Wt.: 322.4
Status: Custom Synthesis

Afatinib Impurity 8

(S)-N4-(3-chlorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
CAT No: VS-A026023
CAS No: N/A
Mol.F.: C18H17ClN4O2?
Mol.Wt.: 356.8
Status: Custom Synthesis

Afatinib Impurity 9

3-((3-chloro-4-fluorophenyl)(6-((E)-4-(dimethylamino)but-2-enamido)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-4-yl)amino)-4-(dimethylamino)butanoic acid
CAT No: VS-A026024
CAS No: N/A
Mol.F.: C30H36ClFN6O5?
Mol.Wt.: 615.1
Status: Custom Synthesis

Afatinib Impurity A

(R)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine
CAT No: VS-A026001
CAS No: 402855-07-6
Mol.F.: C18H14ClFN4O4?
Mol.Wt.: 404.8
Status: Custom Synthesis

Afatinib Impurity B

(S)-N4-(3-Chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine ; N4-(3-Chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4,6-quinazolinediamine
CAT No: VS-A026002
CAS No: 314771-76-1
Mol.F.: C18H16ClFN4O2?
Mol.Wt.: 374.8
Status: Custom Synthesis

Afatinib Impurity C

(R,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
CAT No: VS-A026003
CAS No: 945553-91-3
Mol.F.: C24H25ClFN5O3?
Mol.Wt.: 486
Status: Custom Synthesis

Afatinib Impurity D

(S,Z)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
CAT No: VS-A026004
CAS No: 1680184-59-1
Mol.F.: C24H25ClFN5O3
Mol.Wt.: 486
Status: Custom Synthesis

Afatinib Impurity E

(S,Z)-N-(4-((3,4-dichlorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
CAT No: VS-A026005
CAS No: N/A
Mol.F.: C24H25Cl2N5O3?
Mol.Wt.: 502.4
Status: Custom Synthesis

Afatinib Impurity F

(S,Z)-N-(4-((3,4-difluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
CAT No: VS-A026006
CAS No: 2223677-62-9
Mol.F.: C24H25F2N5O3?
Mol.Wt.: 469.5
Status: Custom Synthesis

Afatinib Impurity G

(S,Z)-N-(4-((4-chloro-3-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide
CAT No: VS-A026007
CAS No: N/A
Mol.F.: C24H25ClFN5O3?
Mol.Wt.: 486
Status: Custom Synthesis

Afatinib Impurity H

(S,Z)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide
CAT No: VS-A026008
CAS No: N/A
Mol.F.: C22H20ClFN4O3?
Mol.Wt.: 442.9
Status: Custom Synthesis

Afatinib Impurity I

(S,Z)-4-bromo-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide
CAT No: VS-A026009
CAS No: N/A
Mol.F.: C22H19BrClFN4O3?
Mol.Wt.: 521.8
Status: Custom Synthesis

Afatinib Impurity J

(S,E)-4-(dimethylamino)-N-(4-oxo-7-((tetrahydrofuran-3-yl)oxy)-1,4-dihydroquinazolin-6-yl)but-2-enamide
CAT No: VS-A026010
CAS No: 1456696-14-2
Mol.F.: C18H22N4O4
Mol.Wt.: 358.4
Status: Custom Synthesis

Afatinib Impurity K

(S,Z)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(methylamino)but-2-enamide
CAT No: VS-A026011
CAS No: N/A
Mol.F.: C23H23ClFN5O3?
Mol.Wt.: 472
Status: Custom Synthesis

Afatinib Impurity-I (Cyclized impurity)

1-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-5-hydroxypyrrolidin-2-one
CAT No: VS-A026047
CAS No: NA
Mol.F.: C22H20ClFN4O4
Mol.Wt.: 458.87
Status: Custom Synthesis

Afatinib Impurity-II (Formyl impurity)

N-{4-[(3-Chloro-4-fluorophenyl)amino]-7- [(3S)-tetrahydrofuran-3-yloxy]quinazolin6-yl} formamide
CAT No: VS-A026048
CAS No: NA
Mol.F.: C19H16ClFN4O3
Mol.Wt.: 402.81
Status: Custom Synthesis

Afatinib Impurity-III (Stage-II intermediate)

N4-(3-Chloro-4-fluorophenyl)-7-[(3S)- tetrahydrofuran-3-yloxy]quinazoline-4,6- diamine
CAT No: VS-A026049
CAS No: NA
Mol.F.: C18H16ClFN4O2
Mol.Wt.: 374.79
Status: Custom Synthesis

Afatinib Impurity-IV (KSM-III)

(2E)-4-(Dimethylamino) but-2-enoic acid Hydrochloride
CAT No: VS-A026056
CAS No: NA
Mol.F.: C6H12ClNO2
Mol.Wt.: 165.61
Status: Custom Synthesis

Afatinib Impurity-IX (Dimer impurity)

N,N'-bis{4-[(3-chloro-4-fluorophenyl) amino]-7-[(3S)- tetrahydrofuran-3-yloxy]- quinazolin-6-yl}ethanediamide
CAT No: VS-A026054
CAS No: NA
Mol.F.: C38H30Cl2F2N8O6
Mol.Wt.: 803.59
Status: Custom Synthesis

Afatinib Impurity-V (Hydroxy impurity)

(2E)-N-{4-[(3-Chloro-4- fluorophenyl)amino]-7- hydroxyquinazolin6-yl}-4- (dimethylamino)but-2-enamide
CAT No: VS-A026050
CAS No: NA
Mol.F.: C20H19ClFN5O2
Mol.Wt.: 415.84
Status: Custom Synthesis

Afatinib Impurity-VI (Difluoro impurity)

(S,E)-N-(4-(3,4-Difluoro phenylamino)-7- (tetra hydrofuran-3-yloxy) quinazolin-6- yl)-4-(dimethylamino)but-2-enamide
CAT No: VS-A026051
CAS No: NA
Mol.F.: C24H25F2N5O3
Mol.Wt.: 469.48
Status: Custom Synthesis

Afatinib Impurity-VII (Dichloro impurity)

(S,E)-N-(4-(3,4-Dichloro phenylamino)-7- (tetra hydrofuran-3-yloxy) quinazolin-6- yl)-4-(dimethylamino)but-2-enamide
CAT No: VS-A026052
CAS No: NA
Mol.F.: C24H25Cl2N5O3
Mol.Wt.: 502.39
Status: Custom Synthesis

Afatinib Impurity-VIII (Crotonamide impurity)

(2E)-N-[4-(3-Chloro-4- fluorophenyl)amino]-7-[[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6- yl]but-2-enamide
CAT No: VS-A026053
CAS No: NA
Mol.F.: C22H20ClFN4O3
Mol.Wt.: 442.87
Status: Custom Synthesis

Afatinib Impurity-X (DMA impurity)

(S)-N1-(4-(3-chloro-4- fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-N2,N2-dimethyl oxalamide
CAT No: VS-A026055
CAS No: NA
Mol.F.: C22H21ClFN5O4
Mol.Wt.: 473.88
Status: Custom Synthesis

Afatinib N-Oxide

(S,E)-4-((4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-2-yl)oxy)quinazolin-6-yl)amino)-N,N-dimethyl-4-oxobut-2-en-1-amine Oxide
CAT No: VS-A026012
CAS No: 2413212-11-8
Mol.F.: C24H25ClFN5O4
Mol.Wt.: 501.9
Status: Custom Synthesis

Afatinib R-Isomer

(2E)-N-[4-(3-Chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydrofuran-3- yloxy]quinazolin-6-yl]-4-(dimethylamino)but-2-enamide
CAT No: VS-A026057
CAS No: NA
Mol.F.: C24H25ClFN5O3
Mol.Wt.: 485.93
Status: Custom Synthesis

Afatinib Sulfonic Acid Analog

4((4-((3-Chloro-4-fluorophenyl) amino)-7-(((S)-tetrahydrofuran-3-yl) oxy) quinazolin-6-yl)amino)-1-(dimethylamino)-4-oxobutane-2-sulfonic acid
CAT No: VS-A026014
CAS No: 2283295-16-7
Mol.F.: C24H27ClFN5O6S
Mol.Wt.: 568
Status: Custom Synthesis

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