Apremilast

Apremilast Related Products

Venkatasai is a leading innovator in the field of pharmaceutical reference standards, offering high-quality Reference Standards of Apremilast, including both pharmacopeial and non-pharmacopeial impurities, metabolites, stable isotope-labeled compounds, and nitrosamines (N-NO products). Our Apremilast impurity reference standards play a vital role in pharmaceutical research, supporting product development, ANDA and DMF filings, quality control (QC), method validation, and stability studies. They are also instrumental in identifying unknown impurities and evaluating genotoxic potential. All Apremilast-related products are thoroughly characterized and supplied with comprehensive Certificates of Analysis (COA) and analytical data that comply with regulatory standards. EP/USP traceable standards can also be provided upon request. Furthermore, all supplied products undergo periodic re-testing to ensure continued quality and reliability.

5-Acetamide Apremilast

(S)-N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-5-yl)acetamide
CAT No: VS-A077040
CAS No: 2201974-01-6
Mol.F.: C22H24N2O7S
Mol.Wt.: 460.5
Status: Custom Synthesis

Apremilast

(S)-N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide
CAT No: VS-A077000
CAS No: 608141-41-9
Mol.F.: C22H24N2O7S
Mol.Wt.: 460.5
Status: Custom Synthesis

Apremilast N-formyl impurity

N-[2-[(1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-formamide
CAT No: VS-A077015
CAS No: 2077897-94-8
Mol.F.: C21H22N2O7S
Mol.Wt.: 446.5
Status: Custom Synthesis

Apremilast 2-Acetamido Benzoic Acid Imurity

2-(Acetylamino)-6-[[[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]amino]carbonyl]-benzoic Acid
CAT No: VS-A077014
CAS No: 1809170-71-5
Mol.F.: C22H26N2O8S
Mol.Wt.: 478.5
Status: Custom Synthesis

Apremilast Des Oxo Impurity

N,N?-(((propane-1,3-diyldisulfonyl)bis(1-(3-ethoxy-4-methoxyphenyl)ethane-2,1-diyl))bis(1,3-dioxoisoindoline-2,4-diyl))diacetamide
CAT No: VS-A077012
CAS No: 2487573-08-8
Mol.F.: C45H48N4O14S2
Mol.Wt.: 933.01
Status: Custom Synthesis

Apremilast Dimer

(S)-N-(2'-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,1',3,3'-tetraoxo-[2,4'-biisoindolin]-4-yl)acetamide
CAT No: VS-A077008
CAS No: 1802246-60-1
Mol.F.: C30H27N3O9S
Mol.Wt.: 605.62
Status: Custom Synthesis

Apremilast EP Impurity B

3-(Acetylamino)-1,2-benzenedicarboxylic Acid;
CAT No: VS-A077001
CAS No: 15371-06-9
Mol.F.: C10H9NO5
Mol.Wt.: 223.18
Status: Custom Synthesis

Apremilast EP Impurity C

4-acetyl-2-(1-(3,4-dimethoxyphenyl)-2-(methylsulfonyl)ethyl)isoindoline-1,3-dione
CAT No: VS-A077002
CAS No: 2487573-02-2
Mol.F.: C21H21NO7S
Mol.Wt.: 431.46
Status: Custom Synthesis

Apremilast EP Impurity D

N-(2-(1-(3,4-diethoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide
CAT No: VS-A077003
CAS No: 2448678-64-4
Mol.F.: C23H26N2O7S
Mol.Wt.: 474.53
Status: Custom Synthesis

Apremilast EP Impurity E

N-(2-(1-(4-ethoxy-3-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide
CAT No: VS-A077004
CAS No: 2487573-03-3
Mol.F.: C22H24N2O7S
Mol.Wt.: 460.5
Status: Custom Synthesis

Apremilast EP Impurity F

2-amino-6-((1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)carbamoyl)benzoic acid
CAT No: VS-A077005
CAS No: N/A
Mol.F.: C20H24N2O7S
Mol.Wt.: 436.48
Status: Custom Synthesis

Apremilast EP Impurity H

1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-amine
CAT No: VS-A077006
CAS No: 253168-94-4
Mol.F.: C12H19NO4S
Mol.Wt.: 273.35
Status: Custom Synthesis

Apremilast Impurity 1

(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-amine acetyl-L-leucinate
CAT No: VS-A077017
CAS No: 608141-43-1
Mol.F.: C12H19NO4S ; C8H15NO3
Mol.Wt.: 273.4 ; 173.2
Status: Custom Synthesis

Apremilast Impurity 10

(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-amine
CAT No: VS-A077026
CAS No: 608141-42-0
Mol.F.: C12H19NO4S
Mol.Wt.: 273.3
Status: Custom Synthesis

Apremilast Impurity 11

N-Desacetyl O4-Desmethyl O3-Desethyl Apremilast ; (S)-4-amino-2-(1-(3,4-dihydroxyphenyl)-2-(methylsulfonyl)ethyl)isoindoline-1,3-dione
CAT No: VS-A077027
CAS No: 1384439-80-8
Mol.F.: C17H16N2O6S
Mol.Wt.: 376.38
Status: Custom Synthesis

Apremilast Impurity 12

N-Desacetyl O4-Desmethyl Apremilast ; (S)-4-amino-2-(1-(3-ethoxy-4-hydroxyphenyl)-2-(methylsulfonyl)ethyl)isoindoline-1,3-dione
CAT No: VS-A077028
CAS No: 1384440-16-7
Mol.F.: C19H20N2O6S
Mol.Wt.: 404.44
Status: Custom Synthesis

Apremilast Impurity 13

(S)-N-(2-(1-(3,4-dihydroxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide
CAT No: VS-A077029
CAS No: 1384439-79-5
Mol.F.: C19H18N2O7S
Mol.Wt.: 418.42
Status: Custom Synthesis

Apremilast Impurity 14

(S)-4-amino-2-(1-(3-hydroxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)isoindoline-1,3-dione
CAT No: VS-A077030
CAS No: 2487573-05-5
Mol.F.: C18H18N2O6S
Mol.Wt.: 390.41
Status: Custom Synthesis

Apremilast Impurity 15

(S)-N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-5-hydroxy-1,3-dioxoisoindolin-4-yl)acetamide
CAT No: VS-A077031
CAS No: 2096492-43-0
Mol.F.: C22H24N2O8S
Mol.Wt.: 476.5
Status: Custom Synthesis

Apremilast Impurity 16

(S)-3-Acetamido-2-((1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl) carbamoyl)benzoic Acid
CAT No: VS-A077032
CAS No: 2096492-41-8
Mol.F.: C22H26N2O8S
Mol.Wt.: 478.52
Status: Custom Synthesis

Apremilast Impurity 17

N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-((2-hydroxyethyl)sulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide
CAT No: VS-A077033
CAS No: 2487573-01-1
Mol.F.: C23H26N2O8S
Mol.Wt.: 490.54
Status: Custom Synthesis

Apremilast Impurity 18

1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-ol
CAT No: VS-A077034
CAS No: 2055542-18-0
Mol.F.: C12H18O5S
Mol.Wt.: 274.33
Status: Custom Synthesis

Apremilast Impurity 19

3-Hydroxy-4-methoxybenzonitrile
CAT No: VS-A077035
CAS No: 52805-46-6
Mol.F.: C8H7NO2
Mol.Wt.: 149.1
Status: Custom Synthesis

Apremilast Impurity 2

N-(1,3-dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide
CAT No: VS-A077018
CAS No: 6296-53-3
Mol.F.: C10H7NO4
Mol.Wt.: 205.2
Status: Custom Synthesis

Apremilast Impurity 20

(S)-5-amino-2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)isoindoline-1,3-dione
CAT No: VS-A077036
CAS No: N/A
Mol.F.: C20H22N2O6S
Mol.Wt.: 418.5
Status: Custom Synthesis

Apremilast Impurity 21

3-ethoxy-4-methoxybenzonitrile
CAT No: VS-A077037
CAS No: 60758-86-3
Mol.F.: C10H11NO2
Mol.Wt.: 177.2
Status: Custom Synthesis

Apremilast Impurity 22

(S)-2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)isoindoline-1,3-dione
CAT No: VS-A077038
CAS No: 2077897-93-7
Mol.F.: C20H21NO6S
Mol.Wt.: 403.4
Status: Custom Synthesis

Apremilast Impurity 25

(S)-2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-5-nitroisoindoline-1,3-dione
CAT No: VS-A077041
CAS No: N/A
Mol.F.: C20H20N2O8S
Mol.Wt.: 448.4
Status: Custom Synthesis

Apremilast Impurity 26

3-(4-acetamido-1,3-dioxoisoindolin-2-yl)phthalic acid
CAT No: VS-A077043
CAS No: N/A
Mol.F.: C18H12N2O7
Mol.Wt.: 368.3
Status: Custom Synthesis

Apremilast Impurity 27

N-(1,3-Dihydro-1,3-dioxo-5-isobenzofuranyl)acetamide
CAT No: VS-A077044
CAS No: 22235-04-7
Mol.F.: C??H?NO?
Mol.Wt.: 205.17
Status: Custom Synthesis

Apremilast Impurity 28

3 -Ethoxy-4-methoxybenzoic acid
CAT No: VS-A077046
CAS No: 2651-55-0
Mol.F.: C10H12O4
Mol.Wt.: 196.2
Status: Custom Synthesis

Apremilast Impurity 29

3-ethoxy-4-methoxybenzaldehyde oxime
CAT No: VS-A077047
CAS No: 1956-36-1
Mol.F.: C10H13NO3
Mol.Wt.: 195.2
Status: Custom Synthesis

Apremilast Impurity 3

(S)-N-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)acetamide
CAT No: VS-A077019
CAS No: 2097600-16-1
Mol.F.: C14H21NO5S
Mol.Wt.: 315.4
Status: Custom Synthesis

Apremilast Impurity 30

3,4-Diethoxybenzonitrile
CAT No: VS-A077048
CAS No: 60758-87-4
Mol.F.: C11H13NO2
Mol.Wt.: 191.2
Status: Custom Synthesis

Apremilast Impurity 31

3-Ethoxy-4-methoxybenzamide
CAT No: VS-A077049
CAS No: 247569-89-7
Mol.F.: C10H13NO3
Mol.Wt.: 195.2
Status: Custom Synthesis

Apremilast Impurity 32

?1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-one
CAT No: VS-A077050
CAS No: 1450657-28-9
Mol.F.: C12H16O5S
Mol.Wt.: 272.3
Status: Custom Synthesis

Apremilast Impurity 33

1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethen-1-amine
CAT No: VS-A077051
CAS No: 2139236-60-3
Mol.F.: C12H17NO4S
Mol.Wt.: 271.3
Status: Custom Synthesis

Apremilast Impurity 34

(R)-1-(3 -ethoxy-4-methoxyphenyl )-2-(methyl sulfonyl) ethan-1-amine
CAT No: VS-A077052
CAS No: 608142-27-4
Mol.F.: C12H19NO4S
Mol.Wt.: 273.3
Status: Custom Synthesis

Apremilast Impurity 35

3-amino-2-(methoxycarbonyl)benzoic acid
CAT No: VS-A077053
CAS No: 113579-20-7
Mol.F.: C9H9NO4
Mol.Wt.: 195.17
Status: Custom Synthesis

Apremilast Impurity 36

2-amino-6-(methoxycarbonyl)benzoic acid
CAT No: VS-A077054
CAS No: 103259-06-9
Mol.F.: C9H9NO4
Mol.Wt.: 195.17?
Status: Custom Synthesis

Apremilast Impurity 37

3-Ethoxy-4-methoxybenzaldehyde
CAT No: VS-A077055
CAS No: 1131-52-8
Mol.F.: C10H12O3
Mol.Wt.: 180.2
Status: Custom Synthesis

Apremilast Impurity 4

(S)-2-acetamido-N-((S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-4-methylpentanamide
CAT No: VS-A077020
CAS No: 1407140-51-5
Mol.F.: C20H32N2O6S
Mol.Wt.: 428.5
Status: Custom Synthesis

Apremilast Impurity 5

(S)-2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-4-nitroisoindoline-1,3-dione
CAT No: VS-A077021
CAS No: 2095036-40-9
Mol.F.: C20H20N2O8S
Mol.Wt.: 448.5
Status: Custom Synthesis

Apremilast Impurity 6

(S)-N-(2-(1-(3-hydroxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide
CAT No: VS-A077022
CAS No: 1384967-20-7
Mol.F.: C20H20N2O7S
Mol.Wt.: 432.5
Status: Custom Synthesis

Apremilast Impurity 8

(S)-N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-7-hydroxy-1,3-dioxoisoindolin-4-yl)acetamide
CAT No: VS-A077024
CAS No: 2096492-44-1
Mol.F.: C22H24N2O8S
Mol.Wt.: 476.5
Status: Custom Synthesis

Apremilast Impurity 9

(E)-2-ethoxy-1-methoxy-4-(2-(methylsulfonyl)vinyl)benzene
CAT No: VS-A077025
CAS No: 1831833-38-5
Mol.F.: C12H16O4S
Mol.Wt.: 256.32
Status: Custom Synthesis

Apremilast Impurity E

4-Amino-2'-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-[2,4'-biisoindoline]-1,1',3,3'-tetraone
CAT No: VS-A077007
CAS No: N/A
Mol.F.: C28H25N3O8S
Mol.Wt.: 563.6
Status: Custom Synthesis

Apremilast Olifin Amine

(Z)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethen-1-amine
CAT No: VS-A077011
CAS No: 1450657-31-4
Mol.F.: C12H17NO4S
Mol.Wt.: 271.33
Status: Custom Synthesis

Apremilast R-Isomer

(R)-N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide
CAT No: VS-A077010
CAS No: 608141-44-2
Mol.F.: C22H24N2O7S
Mol.Wt.: 460.5
Status: Custom Synthesis

Apremilast related compound E

(S)-N-(2-[1-(4-Ethoxy-3-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxoisoindolin-4-yl)acetamide
CAT No: VS-A077056
CAS No: NA
Mol.F.: C22H24N2O7S
Mol.Wt.: 460.5
Status: Custom Synthesis

Desacetyl Apremilast

(S)-4-amino-2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)isoindoline-1,3-dione
CAT No: VS-A077009
CAS No: N/A
Mol.F.: C20H22N2O6S
Mol.Wt.: 418.46
Status: Custom Synthesis

Desacetyl Apremilast

?(S)-4-Amino-2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)isoindoline-1,3-dione
CAT No: VS-A077042
CAS No: 635705-72-5
Mol.F.: C20H22N2O6S
Mol.Wt.: 418.5
Status: Custom Synthesis

2-Desacetylapremilast open chain analog

(S)-2-Amino-6-((1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)carbamoyl)benzoic acid
CAT No: VS-A077039
CAS No: N/A
Mol.F.: C20H24N2O7S
Mol.Wt.: 436.5
Status: Custom Synthesis

4-Hydroxy benzonitrile

3-Ethoxy-4-hydroxybenzonitrile
CAT No: VS-A077045
CAS No: 60758-79-4
Mol.F.: C9H9NO2
Mol.Wt.: 163.2
Status: Custom Synthesis

N-Deacetyl Apremilast

4-Amino-2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)isoindoline-1,3-dione
CAT No: VS-A077013
CAS No: 253168-83-1
Mol.F.: C20H22N2O6S
Mol.Wt.: 418.5
Status: Custom Synthesis

3-Nitrophthalic Acid

3-Nitro-1,2-benzenedicarboxylic Acid
CAT No: VS-A077016
CAS No: 603-11-2
Mol.F.: C8H5NO6
Mol.Wt.: 211.1
Status: Custom Synthesis

O-Desmethyl Apremilast (USP)

(S)-N-(2-(1-(3-ethoxy-4-hydroxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide
CAT No: VS-A077023
CAS No: 1384441-38-6
Mol.F.: C21H22N2O7S
Mol.Wt.: 446.5
Status: Custom Synthesis

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