Venkatasai is a leading innovator in the field of pharmaceutical reference standards, offering high-quality Reference Standards of Aprepitant, including both pharmacopeial and non-pharmacopeial impurities, metabolites, stable isotope-labeled compounds, and nitrosamines (N-NO products). Our Aprepitant impurity reference standards play a vital role in pharmaceutical research, supporting product development, ANDA and DMF filings, quality control (QC), method validation, and stability studies. They are also instrumental in identifying unknown impurities and evaluating genotoxic potential. All Aprepitant-related products are thoroughly characterized and supplied with comprehensive Certificates of Analysis (COA) and analytical data that comply with regulatory standards. EP/USP traceable standards can also be provided upon request. Furthermore, all supplied products undergo periodic re-testing to ensure continued quality and reliability.
Aprepitant
![5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one (as per EP) ; (3-[[(2R,3S)-2-[(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholino]methyl]-1H-1](watermark.php?img=VS-A078000.png)
Aprepitant (R,S,R)-Isomer
![5-([(2S,3R)-2-((R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy)-3-(4-fluoro phenyl)morpholino]methyl)-1H-1,2,4-triazol-3(2H)-one?](watermark.php?img=VS-A078002.png)
Aprepitant (R,S,S)-Isomer
![5-([(2S,3S)-2-((R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy)-3-(4-fluoro phenyl)morpholino]methyl)-1H-1,2,4-triazol-3(2H)-one](watermark.php?img=VS-A078003.png)
Aprepitant (S,R,R)-Isomer
![5-([(2R,3R)-2-((S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy)-3-(4-fluoro phenyl)morpholino]methyl)-1H-1,2,4-triazol-3(2H)-one](watermark.php?img=VS-A078004.png)
Aprepitant (S,R,S)-Isomer
![5-([(2R,3S)-2-((S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy)-3-(4-fluoro phenyl)morpholino]methyl)-1H-1,2,4-triazol-3(2H)-one ;](watermark.php?img=VS-A078005.png)
Aprepitant (S,S,S)-Isomer
![5-([(2S,3S)-2-((S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy)-3-(4-fluoro phenyl)morpholino]methyl)-1H-1,2,4-triazol-3(2H)-one ;](watermark.php?img=VS-A078006.png)
Aprepitant EP Impurity A
![?5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-phenylmorpholin-4-yl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one (as per EP) ; (5-{[(2R,3S)-2-{(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy}-3-phenylmorpholino]methyl}-2H-1,2,4-triazol-3(4H)-](watermark.php?img=VS-A078007.png)
Aprepitant EP Impurity B
![5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4?-fluorobiphenyl-3-yl)morpholin-4-yl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one ( as per EP)](watermark.php?img=VS-A078008.png)
Aprepitant EP Impurity C
![5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4?-fluorobiphenyl-4-yl)morpholin-4-yl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one ( as per EP)](watermark.php?img=VS-A078009.png)
Aprepitant HCl
![5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one hydrochloride (as per EP) ; (3-[[(2R,3S)-2-[(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin](watermark.php?img=VS-A078001.png)
Aprepitant Impurity 1
Aprepitant Impurity 2
Aprepitant Impurity 3
Aprepitant Impurity 4
Aprepitant Impurity 5
Aprepitant Impurity 6
Aprepitant Impurity 7
Aprepitant M2 Metabolite (1R,2R,3R)-Isomer Hydrochloride
Aprepitant M2 Metabolite (1S, 2S, 3R)-Isomer
Aprepitant meta-Fluoro Isomer
![5-([(2R,3S)-2-((R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy)-3-(3-fluoro phenyl)morpholino]methyl)-1H-1,2,4-triazol-3(2H)-one ;](watermark.php?img=VS-A078012.png)
Aprepitant N-Oxide
![5-([(2R,3S)-2-((R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy)-3-(4-fluoro phenyl)-4-oxido-morpholino]methyl)-1H-1,2,4-triazol-3(2H)-one ;](watermark.php?img=VS-A078013.png)
Aprepitant Open-Ring Methyl Ester Impurity
Aprepitant USP Related Compound A
![3-[[(2R,3R)-2-[(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluoro phenyl)morpholino]methyl]-1H-1,2,4-triazol-5(4H)-one (as per USP)](watermark.php?img=VS-A078010.png)
Aprepitant USP Related Compound B
![3-[[(2S,3R)-2-[(S)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluoro phenyl)morpholino]methyl]-1H-1,2,4-triazol-5(4H)-one (as per USP)](watermark.php?img=VS-A078011.png)
N-Nitroso Aprepitant Impurity 2
RRS isomer of Aprepitant
![(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)morpholine](watermark.php?img=VS-A078015.png)
